Abstract Introduction: popliteal pseudoaneurysm is a rare entity and is usually secondary to trauma. A case of traumatic popliteal pseudoaneurysm is presented. Case report: a 74-year-old man with a femur fracture 4 months ago, managed with external tutors prior to final resolution. He presented local bleeding and increased volume of the left lower limb. AngioTC showed a large pseudoaneurysm of the left popliteal artery. We resolve it with endovascular treatment with a covered stent. Discussion: endovascular treatment is an option for the resolution of popliteal pseudoaneurysm. Open surgical treatment should be considered in cases of hemodynamic instability and the possible coexistence of other injuries that require immediate management.

Resumen Introducción: el pseudoaneurisma poplíteo es una entidad infrecuente y suele ser secundario a un trauma. Se presenta el caso de pseudoaneurisma poplíteo traumático. Caso clínico: hombre de 74 años con fractura de fémur hace 4 meses, manejada con implantes externos antes de la resolución definitiva. Presentó sangrado local y aumento del volumen de la extremidad inferior izquierda. El angio TAC evidenció un gran pseudoaneurisma de la arteria poplítea izquierda que se resolvió de manera endovascular con stent cubierto. Discusión: el tratamiento endovascular es una opción para la resolución del pseudoaneurisma poplíteo. El tratamiento quirúrgico abierto debe considerarse en casos de inestabilidad hemodinámica y la posible coexistencia de otras lesiones que requieran manejo inmediato.

Abstract Introduction: COVID-19 infection has been associated with significant coagulation disorders, particularly hypercoagulable states. We present two cases of aortic thrombosis associated with COVID-19 infection and their outcome. Case report: case 1. Patient with asymptomatic aortic arch thrombosis. Case 2. Patient with aortoiliac thrombosis with acute lower extremity ischemia. Discussion: up to 20 % of patients with COVID-19 have some complication, including bleeding disorders. Surgical treatment of patients with COVID-19 infection and arterial complications poses a complex scenario when deciding on therapeutic conduct.

Resumen Introducción: la infección por COVID-19 se ha asociado a importantes alteraciones de la coagulación, en particular a estados de hipercoagulabilidad. Se presentan dos casos de trombosis aórtica asociados a infección por COVID-19 y su desenlace. Caso clínico: caso 1. Paciente con trombosis del arco aórtico asintomática. Caso 2. Paciente con trombosis aortoilíaca con isquemia aguda de extremidades inferiores. Discusión: hasta el 20 % de los pacientes con COVID-19 presenta alguna complicación, incluyendo trastornos de la coagulación. El manejo quirúrgico de pacientes con COVID-19 y complicación arterial plantea un escenario complejo a la hora de decidir la conducta terapéutica.

Abstract Introduction: firearm vascular trauma affects mostly the lower extremities. 2.5 % of cases can be complicated by an arteriovenous fistula. A case of early endovascular treatment of traumatic arteriovenous fistula is presented. Case report: a 26-year-old man suffered a shotgun wound to the lower extremities. AngioCT suggestive of arteriovenous communication at the left popliteal level. Selective angiography revealed traumatic arteriovenous fistula dependent on the genicular artery. In the second stage, selective embolization was performed and closure of the arteriovenous fistula was achieved. Discussion: traumatic arteriovenous fistula is a rare condition. Prompt treatment prevents the development of short and long-term complications.

Resumen Introducción: el trauma vascular por arma de fuego afecta sobre todo a las extremidades inferiores. El 2,5 % de los casos puede complicarse con una fístula arteriovenosa. Se presenta el caso de un tratamiento precoz endovascular de fístula arteriovenosa traumática. Caso clínico: hombre de 26 años que sufrió una herida por escopeta en las extremidades inferiores. El angio-TAC sugiere comunicación arteriovenosa a nivel de la zona poplítea izquierda. La angiografía selectiva reveló una fístula arteriovenosa traumática dependiente de arteria genicular. En una segunda fase se realizó una embolización selectiva y se logró el cierre de la fístula arteriovenosa. Discusión: la fístula arteriovenosa traumática es una patología infrecuente. El tratamiento oportuno evita el desarrollo de complicaciones a corto y a largo plazo.

ABSTRACT Introduction: The high physical demands and risk of injury related to rugby practice make necessary the development of strategies addressed to promote the player´s welfare inside and outside of the playing field, among them, self-care becomes especially important. Objective: To identify the self-care´s knowledge, practices and determinants in rugby players in Bogota, Colombia. Methods: A qualitative study was conducted through semi-structured interviews with six players and one Physiotherapist. Data analysis was performed under the vision of the Theory of Self-Care proposed by Orem. Results: The players relate the concept of self-care to the prevention of injuries and better athletic performance. They assume the risk of injury linked to the sports practice if that contributes to team success. Sports culture and limited resources associated with the amateur practice are determinants of self-care. Conclusions: There are some notions of self-care between the Rugby players. However, their practices are derived from the available resources and sports´ culture, where the desire to play overcomes physical well-being and health care. Further studies that allow the understanding of the dynamics and group needs in order to generate strategies to promote a favourable environment for self-care practices in these players are required.

RESUMEN Introducción: la alta exigencia física y riesgo de lesiones presentes en el rugby hacen necesario el desarrollo de estrategias encaminadas a promover el bienestar del jugador dentro y fuera del terreno de juego; entre ellas, el autocuidado cobra especial importancia. Objetivo: identificar los conocimientos, prácticas y determinantes del autocuidado en jugadores de rugby en Bogotá, Colombia. Métodos: estudio cualitativo, a través de entrevistas semi-estructuradas con seis informantes clave-jugadores y un informante general (fisioterapeuta). El análisis de datos se realizó fundamentado en la Teoría del Autocuidado de Orem. Resultados: los jugadores reconocen la relación de autocuidado con la prevención de lesiones y mejor rendimiento deportivo. Ellos asumen el riesgo de lesiones durante su práctica si contribuyen al triunfo de su equipo. La cultura del deporte y la escasez de recursos asociada a la práctica aficionada son determinantes del autocuidado. Conclusiones: se encuentran algunas nociones sobre autocuidado, sin embargo, existen prácticas derivadas de los recursos disponibles y la cultura deportiva donde el deseo de jugar se sobrepone al bienestar físico y el cuidado de la salud. Es necesario realizar más estudios que permitan comprender las dinámicas y necesidades grupales con el fin de generar estrategias que promuevan un entorno favorable para las prácticas de autocuidado en estos jugadores.

Abstract: Background: Vitiligo is characterized by a lack of pigmentation in the skin. To date, there are no studies that analyze the changes in gene expression in the skin of vitiligo patients in response to narrow-band ultraviolet B (nb-UVB) phototherapy treatment. Objective: Explore the usefulness of new generation RNA sequencing in the identification of gene expression changes in the skin of vitiligo patients treated with nb-UVB phototherapy. Methods: Four skin biopsies (4mm in diameter) were collected from 45 Mexican vitiligo vulgaris patients, 2 specimens before and 2 after treatment with nb-UVB phototherapy, obtained from pigmented and non-pigmented tissue. RNA extracted from the biopsies was analyzed using the Illumina TruSeq Targeted RNA Expression protocol to study the expression of genes that participate in pathways of skin homeostasis. The 2 groups were compared using Student's t-test and the Mann-Whitney U-test. Results: The expression analysis identified differences in 12 genes included in this study after comparing the samples obtained before and after treatment: 5 genes involved in skin pigmentation, 2 genes involved in apoptosis, 2 genes involved in cell survival, 2 genes involved in oxidative stress responses and 1 gene involved in signal transduction mechanisms (p<0.05). Study limitations: The small size of skin biopsies limits the amount of RNA obtained, the number of genes to be analyzed and the use of conventional techniques such as RT-qPCR. Conclusion: We demonstrated usefulness of new generation RNA sequencing in the identification of gene expression changes, in addition to identifying new targets in the study of vitiligo.

Introduction: The Department of Basic Biomedical Sciences at the Universidad Europea de Madrid is committed to design activities that foster an environment of active and inclusive student-centered learning and contextualized in a professional environment. The aim is to ensure, through an integrated assimilation of fundamental concepts, the student motivation to learn and facilitate the extracurricular knowledge. Subjects and methods: Within our added-value activities, we have designed a play-based activity with students from the first course of the degrees of Medicine, Pharmacy and the double degree Pharmacy-Biotechnology. Using a clinical case related to a cardiovascular disease as a thread, a gymkhana was designed following a workstations working model. The correct resolution of all tasks included in each workstation without delay was finally rewarded. Results: Respondents found the integrated sessions more useful than the traditional seminars and also remarked that they bring up a variety of contents from different subjects successfully (54% positive answers). 58% of the survey participants expressed that the activity approached them new content not covered through the traditional master class. Conclusions: We have ensured that students develop skills required to take their future roles as members of multidisciplinary teams, thanks to the participation of students from different degrees. Moreover, the activity managed to increase motivation and the interest for the most basic concepts of Biomedical Sciences through real integration and direct application to a real clinical case. The experience was evaluated as very positive by all participants.

Introducción: Desde el Departamento de Ciencias Biomédicas Básicas de la Universidad Europea de Madrid optamos por el diseño de actividades que fomenten un entorno de aprendizaje activo e integrador, centrado en el alumno y contextualizado en un entorno profesional. El objetivo es favorecer la asimilación de conceptos fundamentales, motivando al alumno y facilitando el aprendizaje extracurricular. Sujetos y métodos: Dentro de nuestras actividades de valor añadido hemos diseñado una dinámica a través del juego con estudiantes de los primeros cursos de los grados de Medicina, Farmacia y la doble titulación de Farmacia-Biotecnología. Utilizando como hilo conductor un caso clínico relacionado con una enfermedad cardiovascular, se diseñó una yincana con un carácter integrador de disciplinas básicas con diferentes estaciones de trabajo. Se premió la correcta resolución de las tareas incluidas en las estaciones de trabajo en un tiempo establecido. Resultados: Los estudiantes encuestados mostraron su satisfacción con la utilidad de estas sesiones integradas frente a las no integradas, así como con la inclusión de contenidos de diferentes materias (el 54% respondió favorablemente). El 58% de los grupos participantes afirmó que la actividad les acercó a contenidos nuevos. Conclusiones: Con esta actividad se ha aumentado el interés y la motivación de los alumnos por los conceptos más básicos de las ciencias biomédicas, a través de la integración real y la aplicación directa a un caso clínico auténtico. Asimismo, hemos conseguido que los alumnos trabajen competencias necesarias para asumir sus futuros roles como integrantes de equipos multidisciplinares, gracias a la participación de alumnos de grados distintos.

La artritis reumatoide (AR) es una enfermedad crónica de naturaleza autoinmune e inflamatoria que conduce a la formación de pannus seguido de la destrucción de las articulaciones, se caracteriza por hiperplasia sinovial, inflamación y angiogénesis. La especie vegetal Baccharis latifolia es utilizada tradicionalmente en muchas regiones de nuestro país para tratar el dolor, la inflamación y la artritis. En el presente estudio se evaluó la actividad antiartrítica del extracto etanólico de B. latifolia en modelos murinos de artritis reumatoide inducida por adyuvante, la estimación del edema/espesor de la pata inflamada, parámetros hematológicos (hemoglobina, velocidad de sedimentación globular, recuento de eritrocitos, recuento total de leucocitos) y observación radiológica fueron evaluados. La administración oral del extracto etanólico de B. latifolia (600 mg/kg de p.c.) inhibió significativamente (p<0.001) el incremento del edema/espesor de la pata en el modelo de artritis subcrónica. Del mismo modo, B. latifolia (500 mg/kg de p.c.) inhibió significativamente el incremento del edema/espesor de la pata en el modelo de artritis crónica (p<0.05, p<0.01), los pesos de los animales se mantuvieron sin variación durante el tratamiento. Por otro lado, los parámetros hematológicos señalan que los niveles de hemoglobina disminuyen en ratones artríticos y que esta disminución es revertida tras la administración de los extractos de B. latifolia, este mismo perfil de recuperación es observado tras el recuento de glóbulos rojos. Adicionalmente, la velocidad de sedimentación globular (VSG) incrementada en ratones artríticos, es revertida tras la administración de B. latifolia. El análisis radiológico evidenció el efecto del extracto etanólico de B. latifolia en el retraso de la destrucción ósea. Los resultados sugieren que el extracto etanólico de B. latifolia tiene una potencial actividad antiartrítica.

Rheumatoid arthritis (RA) is a chronic autoimmune and inflammatory disease leading to pannus formation followed by the destruction of the joints; it is characterized by synovial hyperplasia, inflammation and angiogenesis. The plant species Baccharis latifolia is traditionally used in many regions of our country to treat pain, inflammation and arthritis. In the present study the antiarthritic activity of ethanol extract of B. latifolia was evaluated in murine experimental model of rheumatoid arthritis induced by adjuvant, edema estimation/thickness of the inflamed foot, hematological parameters (hemoglobin, erythrocyte sedimentation rate, erythrocyte count was assessed, total white blood cell) and radiological observation were evaluated. The oral administration of the ethanolic extract of B. latifolia (600 mg / kg p.c.) significantly inhibited (p <0,001) increased edema / paw thickness in the subchronic model of arthritis. Similarly, B. latifolia (500 mg / kg bw) significantly inhibited the increase of edema/paw thickness in the model of chronic arthritis (p <0.05, p <0.01), the weights of the animals were kept without variation during treatment. Moreover hema-tological parameters indícate that hemoglobin levels decrease in arthritic mice and that this decline is reversed after administration of the extracts of B. latifolia, this same profile is observed recovery after red blood cell count. Additionally, erythrocyte sedimentation rate (ESR) increased in arthritic mice is reversed after administration of B. latifolia. The radiological analysis showed the effect of ethanol extract of B. latifolia in delaying bone destruction. The results suggest that the ethanolic extract of B. latifolia has potential antiarthritic activity.

The chemical composition of aristolochic acids (AAs) from the roots of A. chilensis was determined by high-performance liquid chromatography with diode-array detection (HPLC-DAD), a technique widely used for the detection and quantification of AAs in herbal medicines. The roots contained a mixture of AA-I (1), AA-II (2), AA-III (3), AA-IV (4), AA-Ia (5), AA-IIIa (6), AA-IVa (7), and aristoloside (8), indicating that A. chilensis is not suitable for use as a medicinal plant due to the harmful effects of the aristolochic acids.

The compositions of the essential oils (EO's) obtained by hydro distillation from fresh leaves of Haplopappus foliosus and Bahia ambrosoides was analyzed by gas chromatography/mass spectroscopy (GC/MS). The insecticidal activity of each oil against the house fly Musca domestica was evaluated by placing flies in a glass jar with a screw cap that held a piece of EO-treated cotton yarn. The dose necessary to kill 50% of flies (LC50) in 1 h was determined at 26±1°C. The essential oil from Haplopappus foliosus was the most potent insecticide (LC50= 4.43 mg/dm³), wile the EO from Bahia ambrosoides shows only moderated insecticide activity (LC50= 19.27 mg/dm³). Accordingto GC and GC/MS analysis, limonene (28,00%); epi-bicyclosesquiphellandrene (9,84%); bornyl acetate (7,74%); 4-terpineol (6,36%);p-cymene (6,00%); agarospirol (5,53%); α-muurolene (4,34%); δ-cadinene (3,98%) and caryophyllene (3,97%) were the principal components of Haplopappus foliosus EO and limonene (28,16%); α-pinene (11,12%); germacrene D (8,81%); sabinene (5,93%); α-thujene (3,48%); γ-curcumene (3,45%) y α-bergamotene (3,36%) were the principal components of Bahia ambrosoides EO. The EO from Haplopappus foliosus seem promising as a natural insecticide against houseflies and the difference with the activity of the EO of Bahia ambrosoides can be ascribed to the content of oxygenated monoterpenoids and sesquiterpenoids.

The present study confrms the hypothesis that aristolochic acids are present in Aristolochia bridgesii. The chemical composition of aristolochic acids in this species is qualitatively similar to that of Aristolochia chilensis, with the two species differing only in the total amount of aristolochic acids present, and in the relative proportions of each aristolochic acid. These results are consistent with the fact that the two Aristolochia species in Chile both serve as host plants to Battus polydamas archidamas (Lepidoptera, Papilionidae, Troidinii).

The multidisciplinary Institutional Committee of experts in Systemic Arterial Hypertension from the National Institute of Cardiology "Ignacio Chávez" presents its update (2008) of "Guidelines and Recommendations" for the early detection, control, treatment and prevention of Hypertension. The boarding tries to be simple and realistic for all that physicians whom have to face the hypertensive population in their clinical practice. The information is based in the most recent scientific evidence. These guides are principally directed to hypertensive population of emergent countries like Mexico. It is emphasized preventive health measures, the importance of the no pharmacological actions, such as good nutrition, exercise and changes in life style, (which ideally it must begin from very early ages). "We suggest that the changes in the style of life must be vigorous, continuous and systematized, with a real reinforcing by part of all the organisms related to the health education for all population (federal and private social organisms). It is the most important way to confront and prevent this pandemic of chronic diseases". In this new edition the authors amplifies the information and importance on the matter. The preventive cardiology must contribute in multidisciplinary entailment. Based mainly on national data and the international scientific publications, we developed our own system of classification and risk stratification for the carrying people with hypertension, Called HTM (Arterial Hypertension in Mexico) index. Its principal of purpose this index is to keep in mind that the current approach of hypertension must be always multidisciplinary. The institutional committee of experts reviewed with rigorous methodology under the principles of the evidence-based medicine, both, national and international medical literature, with the purpose of adapting the concepts and guidelines for a better control and treatment of hypertension in Mexico. This work group recognizes that hypertension is not an isolated disease; therefore its approach must be in the context of the prevalence and interaction with other cardiovascular risk factors such as obesity, diabetes, dislipidemia and smoking among others. The urgent necessity is emphasized to approach in a concatenated form the diverse cardiovascular risk factors, since independently of which they share common pathophysiological mechanisms, its suitable identification and control will affect without any doubt the natural history of the other concatenated risk factor. By all means that to greater participation of factors, greater it will be the global cardiovascular risk but never, however, the specific weight is due to avoid that each one has on the global cardiovascular risk. In this Second edition we try to amplify and give systematic forms for the clinical approach for the suspicion of secondary hypertension and we emphasizes that hypertension in the woman with or without menopause should be careful analyzed, and special recommendations are given for the hypertension in pregnancy. Also we have approached some aspects related to the hypertensive emergencies and other special situations. In this second version some recommendations are presented for boarding hypertension in children and adolescents.

El Comité Institucional multidisciplinario de expertos en Hipertensión Arterial del Instituto Nacional de Cardiología presenta la actualización 2008 de sus "Guías y Recomendaciones" para la detección control y tratamiento de la Hipertensión Arterial Sistémica (HTAS). El abordaje pretende ser simple y práctico para todo aquel médico que tenga que enfrentar a las personas con HTAS, sin sacrificar desde luego, los conocimientos científicos de vanguardia. Estas guías están dirigidas a la población hipertensa de México. Se enfatiza la necesidad de medidas preventivas, la importancia del manejo no farmacológico, tales como nutrición, ejercicio y cambios en el estilo de vida, (que idealmente debe iniciarse desde edades muy tempranas) es crucial para la prevención clínica de cualquier enfermedad crónica esencial del adulto y la hipertensión no escapa a este aspecto. "Sólo si se sistematizan medidas de cambios en el estilo de vida robustos y continuos, con reforzamiento por parte de todos los organismos relacionados con la educación poblacional y el compromiso social habremos de confrontar de manera real y preventiva esta pandemia de enfermedades crónicas". En esta nueva edición de lineamientos se amplifica la información e importancia al respecto. La cardiología preventiva debe contribuir en vinculación multidisciplinaria. Basados principalmente en datos nacionales y lo informado en el resto del mundo, se propone un sistema propio de clasificación y estratificación de riesgo para las personas portadoras de HTAS, denominado HTM (Hipertensión Arterial en México) y tiene como finalidad siempre tener en mente que el abordaje de la HTAS es y será siempre multidisciplinario. El comité de expertos se dio a la tarea de revisar de manera crítica y exhaustiva, bajo los principios de la medicina basada en evidencia, la información más destacada vertida en la literatura médica nacional e internacional, con la finalidad de adecuar los conceptos y lineamientos para un mejor control y tratamiento de la HTAS en México. Una de las conclusiones más relevantes de este grupo de trabajo fue el reconocer que la HTAS no es un ente aislado, sino que, debe abordarse en el contexto de la prevalencia e interacción con otras ECEA así como de otros factores de riesgo tales como obesidad, diabetes, dislipidemia y tabaquismo entre otros. Se enfatiza la necesidad urgente de abordar de forma concatenada los diversos factores de riesgo cardiovascular, ya que independientemente de que comparten mecanismos fisiopatológicos comunes, su adecuada identificación y control afectará sin duda la historia natural del otro factor de riesgo concatenado. Por supuesto que a mayor participación de factores, mayor será el riesgo cardiovascular pero jamás se debe soslayar el peso específico que cada uno tiene sobre el riesgo cardiovascular global. En esta Segunda edición se amplifica de forma práctica el abordaje clínico ante la sospecha de HTAS tanto esencial como secundaria y se enfatiza la HTAS en la mujer con menopausia, y la hipertensión del embarazo. También se abordan algunos aspectos relacionados con las urgencias hipertensivas y otras situaciones especiales. Por primera vez aparecen en estas guías recomendaciones para el abordaje en niños y adolescentes.

Surface compounds were obtained by a methylene chloride extraction of fresh flower heads of Flourensia thurifera. The methylene chloride extract was purified by column chromatography and analyzed by GC-MS, leading to the identification of several monoterpenes, sesquiterpenes and diterpenes. A hydrocarbon fraction of n-alkanes from C23 to C31 and C33 was also identified. Headspace analysis of the fresh flower heads was also carried out. Different proportions of the same mono- and some of the sesquiterpenes were identified in the volatile fraction. The presence of mono- and sesquiterpenes in the flower heads is in agreement with the fact that these families of compounds have been identified in other Flourensiaspecies

The chemical compositions of the flower heads of H. berterii and of Chrysantemum coronarium L., visited by a varied entomofauna, were compared in the search of possible correlations that might explain why different plants are visited by the same insects. Though some similarities were observed in the flavonoid contents of both species, their overall composition was dramatically different, pointing to the existence of rather complex mechanisms of insect attraction by these species. Our results thus represent a cautionary remark to interpretations of such mechanisms based solely on the chemical composition of the volatile components of flowers in the field

Objective. To develop, apply, and evaluate an educational model for the primary prevention of sexually transmitted diseases (STDs) and acquired immunodeficiency syndrome (AIDS) that was based on the sexual knowledge, attitudes, and practices (KAPs) of adolescents and on their perceptions and behaviors in this area, with the ultimate goal of helping develop educational tools to prevent infection with STDs and the human immunodeficiency virus (HIV). Methods. An STD/HIV/AIDS primary prevention model was applied with adolescent schoolchildren (12 to 15 years old) in the canton of Santo Domingo de los Colorados, Ecuador. Two groups with similar characteristics were formed: the experimental group, with 358 students, and the control group, with 288 students. Schools were selected according to inclusion criteria, and adolescents at each school were chosen at random. A discussion guide was applied with 16 focus groups, and the resulting information was used to prepare a KAP survey. After being validated, the KAP survey was applied to the experimental group and to the control group. A prevention education program geared to students and teachers was implemented with the experimental group. Eight months later a second KAP survey was done with the experimental group and the control group. The differences in KAPs before and after the intervention were evaluated using the chi-square test. Results. There were no statistically significant differences between the two groups before the intervention, but afterwards the differences were statistically significant (P = 0.012), with an increase in the knowledge of sexuality and STDs/AIDS in the experimental group, even though the long-term behavior changes have not been evaluated. Conclusions. This study validated a multifactorial STD/AIDS prevention model adapted to the reality of adolescents, and it suggests the possibility of extrapolating this experience more broadly to contexts similar to those of this Ecuador population.

Objetivos. Desarrollar, aplicar y evaluar un modelo educativo de prevención primaria de enfermedades de transmisión sexual (ETS) y síndrome de inmunodeficiencia adquirida (sida) basado en los conocimientos, actitudes y prácticas (CAP) sexuales de los adolescentes y en sus percepciones y conductas al respecto, con el objetivo final de contribuir al desarrollo de herramientas educativas de prevención de las ETS y de la infección por virus de la inmunodeficiencia humana (VIH). Métodos. Se aplicó un modelo de prevención primaria de ETS y VIH/sida a escolares adolescentes (12 a 15 años) de Santo Domingo de los Colorados, Ecuador. Se formaron dos grupos con características similares: el grupo de intervención (grupo I, n = 358) y el grupo de control (grupo C, n = 288). Las escuelas se seleccionaron por criterios de inclusión, y los adolescentes de cada escuela, al azar. Se aplicó una guía de discusión a 16 grupos focales; con esta información se elaboró una encuesta sobre conocimientos, actitudes y prácticas (CAP) que, después de su validación, fue aplicada a ambos grupos. En el grupo I se implementó un programa educativo de prevención dirigido a estudiantes y docentes. Ocho meses más tarde se aplicó una segunda encuesta CAP a los dos grupos. Las diferencias en los CAP antes y después de la intervención fueron evaluadas utilizando la prueba de la ji². Resultados. No existieron diferencias significativas entre los dos grupos antes de la intervención, pero después de ella las diferencias fueron estadísticamente significativas (P = 0,012); se verificó un aumento de conocimientos sobre sexualidad y ETS/sida en el grupo I, aunque todavía no se ha evaluado la modificación de conductas a largo plazo. Conclusiones. Este estudio permitió validar un modelo multifactorial de prevención de ETS/sida adecuado a la realidad de los adolescentes, y sugiere la posibilidad de extrapolar la experiencia a escalas mayores en contextos similares a los de la población investigada.